Profound 2019-02-08T11:15:55-04:00


Skin maintains a youthful appearance by producing collagen, elastin, and hyaluronic acid which provide elasticity and tensile strength. Around age 30, the body begins to make less of each of these key skin components, with catabolic (or break down) of skin exceeding anabolic (or restorative) activity. This loss of dermal volume leads to laxity and wrinkles. This aging process can be slowed and potentially reversed by treatment with Profound—a break-through aesthetic system from Syneron (Figure 1).

By increasing the relative level of anabolic to catabolic activity after treatment, Profound promotes production of collagen, elastin and hyaluronic acid to restore a youthful appearance. The Profound system is the first minimally invasive aesthetic device designed for the treatment of aging skin. Let’s take a look at how the system works.

An innovative micro-needle electrode array is used to deliver RF energy to the skin.1,2 When activated, the electrode array is deployed within the reticular dermis. This minimally invasive approach enables sensors within the electrode tips to be strategically positioned in the tissue being treated (Figure 2).

First, the sensors measure tissue impedance to verify proper electrode placement. Bipolar RF energy is then delivered between the electrode pairs, creating controlled, fractional treatment zones. During energy delivery, tissue temperature and impedance are actively monitored and used to control the treatment (Figure 3).

Physicians can—for the first time—select optimal tissue temperature of 67°C and 4 sec duration as clinical endpoints, which has been shown to maximize clinical results in previously published studies. (Figure 4)

The Profound system then optimizes energy delivery based on real-time feedback from the tissue. As a result, treatments are customized for each patient based on their skin response, ensuring consistent and predictable clinical results.1 At the end of each treatment cycle, the electrodes are automatically withdrawn, and the device is repositioned and activated on the next treatment area. By protecting the epidermis and key adnexal structures while delivering fractional treatment patterns, Profound sets the stage for optimal healing.

The skin cells quickly respond to the treatment by releasing an arsenal of cytokines—the proteins responsible for promoting the wound healing process. The initial cytokine response recruits macrophages to begin removing damaged tissue. Macrophages then release a second set of cytokines to recruit fibroblasts to the site of injury. Fibroblasts are the key anabolic cells that will replace heated tissue and restore the skin to a more youthful state. As healing progresses, macrophages decline and fibroblasts increase, resulting in the production of new elastin, collagen, and hyaluronic acid (Figure 5).

In scientific studies, Profound has been shown to increase the relative level of anabolic activity to catabolic. The catabolic enzymes, MMP-1 and MMP-3, normally responsible for degrading collagen, remain at uniquely low levels of activity, while MMP-9 and MMP-13, which help remodel the newly formed skin, are elevated.5 The surge of regenerative activity significantly increases skin thickness and volume (Figure 6). This dermal remodeling process accelerates during the first two months following treatment and continues for 6 to 12 months. Wrinkles diminish, laxity is improved and the skin becomes more supportive, restoring a lasting, natural, more youthful appearance.

In a prospective multi-center study, response rates of 95% and 100% for facial laxity and rhytids have been observed at 6-month follow-up following a Profound treatment.3 With consistently predictable results like these, you can expect highly satisfied patients and a strong base of referrals. The Profound Fractional Radiofrequency system from Syneron—a ground-breaking aesthetic treatment for your patients and your practice.